Blood loss associated with radical cystectomy: a prospective, randomized study comparing Impact LigaSure vs. stapling device.

Thompson IM, Kappa SF, Morgan TM, Barocas DA, Bischoff CJ, Keegan KA, Stratton KL, Clark PE, Resnick MJ, Smith JA, Cookson MS, Chang SS
Urol Oncol. 2014 32 (1): 45.e11-5

PMID: 24054870 · PMCID: PMC4469381 · DOI:10.1016/j.urolonc.2013.06.006

OBJECTIVES - Radical cystectomy (RC) is associated with significant blood loss and transfusion requirement. We performed a prospective, randomized trial to compare blood loss, operative time, and cost using 2 different and commonly employed approaches to tissue ligation and division during RC: mechanical (stapler device) and electrosurgical (heat-sealing device).

METHODS AND MATERIALS - Eighty patients undergoing RC for urothelial bladder carcinoma were randomized to use of either an Endo GIA Stapler or Impact LigaSure device for tissue ligation and division. Primary outcomes were blood loss, operative time, and device costs. Data were analyzed with Wilcoxon rank sum test and Welch 2-sample t test.

RESULTS - There were no significant demographic or preoperative differences between the cohorts. Mean estimated blood loss was similar between the electrosurgical (687 ml) and stapler (708 ml) arms (P = 0.850). There were no significant differences between cohorts when comparing operative times or transfusion requirement. There was a significant increase in the mean number of adjunctive suture ligatures used in the stapling device arm (3.0 vs. 1.5, P = 0.047). Total device costs were significantly lower with the LigaSure compared with the GIA Stapler ($625.00 vs. $1490.10, P<0.001). There were no complications attributable to either device.

CONCLUSIONS - This prospective, randomized study demonstrates no significant difference in blood loss, transfusion requirement, or safety between mechanical vs. electrosurgical control of the vascular pedicles. The LigaSure device, however, is significantly less costly than the GIA Stapler and required fewer additional measures for hemostasis.

Copyright © 2014 Elsevier Inc. All rights reserved.

MeSH Terms (14)

Aged Blood Loss, Surgical Blood Transfusion Carcinoma, Transitional Cell Cystectomy Female Humans Ligation Male Middle Aged Outcome Assessment (Health Care) Prospective Studies Sutures Urinary Bladder Neoplasms

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