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Vitamin K intake, body mass index and warfarin maintenance dose.

Kabagambe EK, Beasley TM, Limdi NA
Cardiology. 2013 126 (4): 214-8

PMID: 24052022 · PMCID: PMC4038335 · DOI:10.1159/000354218

BACKGROUND - Warfarin inhibits vitamin K-dependent coagulation factors. Being fat-soluble, the availability of vitamin K may vary according to body fat. We hypothesized that body mass index (BMI), a proxy of body fat, may interact with vitamin K intake in determining a warfarin maintenance (WM) dose.

METHODS - Patients with data on vitamin K intake, potential confounders and WM dose (n = 172) were included in linear regression models to test whether BMI modifies the relation between vitamin K intake and WM dose.

RESULTS - Warfarin loading dose correlated with the maintenance dose (r = 0.36, p < 0.0001) but was not significantly associated with WM dose in analyses adjusted for vitamin K epoxide reductase (VKORC1) and cytochrome P450 2C9 (CYP2C9) genotypes. In fully adjusted models, BMI was associated (p = 0.001) with WM dose but vitamin K was only marginally positively associated (p = 0.06) with WM dose. We found no interaction (p > 0.05) between BMI and vitamin K intake with regard to WM dose. Inclusion of vitamin K intake in the model only slightly improved the amount of variance (1.1%) explained by age, gender, BMI, race, physical activity, energy intake and VKORC1 and CYP2C9 genotypes.

CONCLUSION - Our data suggest that body fat does not affect the relation between vitamin K intake and WM dose.

MeSH Terms (12)

Aged Aged, 80 and over Anticoagulants Body Mass Index Female Humans Male Middle Aged Pharmacogenetics Prospective Studies Vitamin K Warfarin

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