Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.

Hargrove TY, Wawrzak Z, Alexander PW, Chaplin JH, Keenan M, Charman SA, Perez CJ, Waterman MR, Chatelain E, Lepesheva GI
J Biol Chem. 2013 288 (44): 31602-15

PMID: 24047900 · PMCID: PMC3814756 · DOI:10.1074/jbc.M113.497990

MeSH Terms (10)

14-alpha Demethylase Inhibitors Antiprotozoal Agents Chagas Disease Crystallography, X-Ray Humans Protozoan Proteins Sterol 14-Demethylase Thiazoles Triazoles Trypanosoma cruzi

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