Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.

Aldred KJ, Schwanz HA, Li G, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
ACS Chem Biol. 2013 8 (12): 2660-8

PMID: 24047414 · PMCID: PMC3870039 · DOI:10.1021/cb400592n

MeSH Terms (20)

Anti-Bacterial Agents Antigens, Neoplasm Bacillus anthracis Cations, Divalent DNA, Bacterial DNA-Binding Proteins DNA Cleavage DNA Topoisomerase IV DNA Topoisomerases, Type II Drug Resistance, Bacterial Humans Kinetics Magnesium Mutation Quinazolinones Quinolones Recombinant Proteins Species Specificity Structure-Activity Relationship Water

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