Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo.

Nelson CE, Kintzing JR, Hanna A, Shannon JM, Gupta MK, Duvall CL
ACS Nano. 2013 7 (10): 8870-80

PMID: 24041122 · PMCID: PMC3857137 · DOI:10.1021/nn403325f

MeSH Terms (10)

Blood Circulation Cations Cell Line, Tumor Endosomes Half-Life Humans Hydrophobic and Hydrophilic Interactions Polyethylene Glycols RNA, Small Interfering Tissue Distribution

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