Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease.

Wang F, Jiang RT, Tantawy MN, Borza DB, Takahashi K, Gore JC, Harris RC, Takahashi T, Quarles CC
J Magn Reson Imaging. 2014 39 (4): 866-71

PMID: 24006202 · PMCID: PMC3858530 · DOI:10.1002/jmri.24242

PURPOSE - To evaluate the repeatability of MRI-derived relative blood volume (RBV) measurements in mouse kidneys across subjects and days and to evaluate sensitivity of this approach to renal pathology.

MATERIALS AND METHODS - A 7 Tesla MRI system and an intravascular iron-oxide contrast agent were used to acquire spin-echo-based renal RBV maps in 10 healthy mice on 2 consecutive days. Renal RBV maps were also acquired in the Alport and unilateral ureteral obstruction mouse models of renal disease.

RESULTS - The average renal RBV measured on consecutive days was 19.97 ± 1.50 and 19.86 ± 1.62, yielding a concordance correlation coefficient of 0.94, indicating that this approach is highly repeatable. In the disease models, the RBV values were regionally dissimilar and substantially lower than those found in control mice.

CONCLUSION - In vivo renal iron-oxide-based RBV mapping in mice complements the physiological information obtained from conventional assays of kidney function and could shed new insights into the pathological mechanisms of kidney disease.

Copyright © 2013 Wiley Periodicals, Inc.

MeSH Terms (17)

Algorithms Animals Blood Flow Velocity Blood Volume Blood Volume Determination Image Enhancement Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Kidney Diseases Kidney Function Tests Magnetic Resonance Angiography Male Mice Mice, Inbred C57BL Renal Circulation Reproducibility of Results Sensitivity and Specificity

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