Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.

Blobaum AL, Bridges TM, Byers FW, Turlington ML, Mattmann ME, Morrison RD, Mackie C, Lavreysen H, Bartolomé JM, Macdonald GJ, Steckler T, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR, Daniels JS
Drug Metab Dispos. 2013 41 (12): 2066-75

PMID: 24003250 · PMCID: PMC3834130 · DOI:10.1124/dmd.113.052662

MeSH Terms (19)

Allosteric Regulation Animals Cytochrome P-450 CYP3A Drug Interactions Hepatocytes Humans Intestinal Mucosa Intestines Ketoconazole Kinetics Liver Male Mice Microsomes Microsomes, Liver Midazolam Mixed Function Oxygenases Rats Rats, Sprague-Dawley

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