Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2.

Rexer BN, Ghosh R, Narasanna A, Estrada MV, Chakrabarty A, Song Y, Engelman JA, Arteaga CL
Clin Cancer Res. 2013 19 (19): 5390-401

PMID: 23948973 · PMCID: PMC3809918 · DOI:10.1158/1078-0432.CCR-13-1038

MeSH Terms (24)

Amino Acid Substitution Animals Antineoplastic Agents Breast Neoplasms Catalysis Cell Line, Tumor Cell Proliferation Cell Survival Codon Disease Models, Animal Drug Resistance, Neoplasm ErbB Receptors Female Gene Amplification Gene Expression Humans Ligands Mice Mutation Phosphatidylinositol 3-Kinases Protein Kinase Inhibitors Receptor, ErbB-2 Receptor, ErbB-3 Xenograft Model Antitumor Assays

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