Quantum dot approaches for target-based drug screening and multiplexed active biosensing.

Kovtun O, Arzeta-Ferrer X, Rosenthal SJ
Nanoscale. 2013 5 (24): 12072-81

PMID: 23946011 · DOI:10.1039/c3nr02019c

Biomolecule detection using quantum dots (Qdots), nanometer-sized semiconductor crystals, effectively addresses the limitations associated with conventional optical and biochemical techniques, as Qdots offer several key advantages over traditional fluorophores. In this minireview, we discuss the role of Qdots as a central nanoscaffold for the polyvalent assembly of multifunctional biomolecular probes and describe recent advances in Qdot-based biorecognition. Specifically, we focus on Qdot applications in target-based, drug screening assays and real-time active biosensing of cellular processes.

MeSH Terms (9)

Animals Binding, Competitive Biosensing Techniques Drug Evaluation, Preclinical Endpoint Determination Humans Molecular Targeted Therapy Quantum Dots Surface Properties

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