Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.

Manka JT, Rodriguez AL, Morrison RD, Venable DF, Cho HP, Blobaum AL, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA
Bioorg Med Chem Lett. 2013 23 (18): 5091-6

PMID: 23932792 · PMCID: PMC3901432 · DOI:10.1016/j.bmcl.2013.07.029

MeSH Terms (12)

Allosteric Regulation Animals Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Dose-Response Relationship, Drug Enzyme Inhibitors Humans Molecular Structure Pyrroles Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship

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