An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.

Garner AP, Bialucha CU, Sprague ER, Garrett JT, Sheng Q, Li S, Sineshchekova O, Saxena P, Sutton CR, Chen D, Chen Y, Wang H, Liang J, Das R, Mosher R, Gu J, Huang A, Haubst N, Zehetmeier C, Haberl M, Elis W, Kunz C, Heidt AB, Herlihy K, Murtie J, Schuller A, Arteaga CL, Sellers WR, Ettenberg SA
Cancer Res. 2013 73 (19): 6024-35

PMID: 23928993 · PMCID: PMC3924863 · DOI:10.1158/0008-5472.CAN-13-1198

MeSH Terms (25)

Animals Antibodies, Monoclonal, Humanized Breast Neoplasms Cell Proliferation ErbB Receptors Female Humans Immunoblotting Immunoprecipitation Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, Nude Mice, SCID Neuregulin-1 Phosphorylation Protein Conformation Protein Multimerization Proto-Oncogene Proteins c-akt Receptor, ErbB-2 Receptor, ErbB-3 Signal Transduction Survival Rate Tumor Cells, Cultured Xenograft Model Antitumor Assays

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