Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation.

Aldrovandi M, Hammond VJ, Podmore H, Hornshaw M, Clark SR, Marnett LJ, Slatter DA, Murphy RC, Collins PW, O'Donnell VB
J Lipid Res. 2013 54 (11): 3085-97

PMID: 23883581 · PMCID: PMC3793613 · DOI:10.1194/jlr.M041533

MeSH Terms (21)

Aspirin Blood Platelets Calcium Cyclooxygenase 1 Cyclooxygenase Inhibitors Dinoprostone Dose-Response Relationship, Drug Esterification Feedback, Physiological Humans Intracellular Space MAP Kinase Kinase 1 Phosphatidylethanolamines Phospholipids Platelet Activation Prostaglandin D2 Prostaglandins Protein Kinase C Receptor, PAR-1 src-Family Kinases Thrombin

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