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Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA
Am J Physiol Heart Circ Physiol. 2013 305 (7): H1068-79

PMID: 23873796 · PMCID: PMC5504390 · DOI:10.1152/ajpheart.00401.2013

MeSH Terms (25)

Acetanilides Animals Calcium Channels, L-Type Calcium Signaling Disease Models, Animal Disease Progression Dose-Response Relationship, Drug Heart Failure Hypertension Hypertrophy, Left Ventricular Male Myocytes, Cardiac NAV1.5 Voltage-Gated Sodium Channel Piperazines Ranolazine Rats Rats, Inbred SHR Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Calcium-Transporting ATPases Sodium Sodium-Calcium Exchanger Sodium Channel Blockers Sodium Channels Time Factors Ultrasonography

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