Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.

Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ
Cell Signal. 2013 25 (11): 2198-209

PMID: 23872073 · DOI:10.1016/j.cellsig.2013.07.007

MeSH Terms (26)

Animals Benzothiazoles Connective Tissue Growth Factor Endothelium, Vascular ErbB Receptors Fibroblasts Fibrosis Gene Expression Regulation Isoquinolines Mice Mink Myocytes, Smooth Muscle Pyridines Pyrroles Quinazolines Rats Reactive Oxygen Species Renal Insufficiency, Chronic Serpin E2 Signal Transduction Smad2 Protein Smad3 Protein Toluene Transforming Growth Factor beta1 Tumor Suppressor Protein p53 Tyrphostins

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