A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

Rad R, CadiƱanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF, Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W, Vassiliou G, Kirchner T, McDermott U, Liu P, Saur D, Bradley A
Cancer Cell. 2013 24 (1): 15-29

PMID: 23845441 · PMCID: PMC3706745 · DOI:10.1016/j.ccr.2013.05.014

MeSH Terms (15)

Animals Cell Transformation, Neoplastic Colorectal Neoplasms Cyclin-Dependent Kinase Inhibitor p16 Drug Screening Assays, Antitumor MAP Kinase Signaling System Mice Microsatellite Instability Mutation Neoplasm Invasiveness Neoplasm Proteins Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins B-raf Tumor Suppressor Protein p53 Wnt Signaling Pathway

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