BRAF: a driver of the serrated pathway in colon cancer.

Rustgi AK
Cancer Cell. 2013 24 (1): 1-2

PMID: 23845435 · DOI:10.1016/j.ccr.2013.06.008

In this issue of Cancer Cell, Rad and colleagues report findings that underscore the importance of oncogenic BRAF mutation coupled with microsatellite instability, p16Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development. These findings provide translational insights into potential therapeutic intervention for BRAF mutant colon cancers.

Copyright © 2013 Elsevier Inc. All rights reserved.

MeSH Terms (10)

Colonic Neoplasms Genes, p16 Genes, p53 Humans Microsatellite Instability Mutation Proto-Oncogene Proteins Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins p21(ras) ras Proteins

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