Community diarrhea incidence before and after rotavirus vaccine introduction in Nicaragua.

Becker-Dreps S, Meléndez M, Liu L, Zambrana LE, Paniagua M, Weber DJ, Hudgens MG, Cáceres M, Källeståll C, Morgan DR, Espinoza F, Peña R
Am J Trop Med Hyg. 2013 89 (2): 246-50

PMID: 23817336 · PMCID: PMC3741244 · DOI:10.4269/ajtmh.13-0026

We estimated the incidence of watery diarrhea in the community before and after introduction of the pentavalent rotavirus vaccine in León, Nicaragua. A random sample of households was selected before and after rotavirus vaccine introduction. All children < 5 years of age in selected households were eligible for inclusion. Children were followed every 2 weeks for watery diarrhea episodes. The incidence rate was estimated as numbers of episodes per 100 child-years of exposure time. A mixed effects Poisson regression model was fit to compare incidence rates in the pre-vaccine and vaccine periods. The pre-vaccine cohort (N = 726) experienced 36 episodes per 100 child-years, and the vaccine cohort (N = 826) experienced 25 episodes per 100 child-years. The adjusted incidence rate ratio was 0.60 (95% confidence interval [CI] 0.40, 0.91) during the vaccine period versus the pre-vaccine period, indicating a lower incidence of watery diarrhea in the community during the vaccine period.

MeSH Terms (11)

Child, Preschool Cohort Studies Diarrhea Female Humans Incidence Infant Male Nicaragua Rotavirus Infections Rotavirus Vaccines

Connections (1)

This publication is referenced by other Labnodes entities:

Links