Community diarrhea incidence before and after rotavirus vaccine introduction in Nicaragua.

Becker-Dreps S, Meléndez M, Liu L, Zambrana LE, Paniagua M, Weber DJ, Hudgens MG, Cáceres M, Källeståll C, Morgan DR, Espinoza F, Peña R
Am J Trop Med Hyg. 2013 89 (2): 246-50

PMID: 23817336 · PMCID: PMC3741244 · DOI:10.4269/ajtmh.13-0026

We estimated the incidence of watery diarrhea in the community before and after introduction of the pentavalent rotavirus vaccine in León, Nicaragua. A random sample of households was selected before and after rotavirus vaccine introduction. All children < 5 years of age in selected households were eligible for inclusion. Children were followed every 2 weeks for watery diarrhea episodes. The incidence rate was estimated as numbers of episodes per 100 child-years of exposure time. A mixed effects Poisson regression model was fit to compare incidence rates in the pre-vaccine and vaccine periods. The pre-vaccine cohort (N = 726) experienced 36 episodes per 100 child-years, and the vaccine cohort (N = 826) experienced 25 episodes per 100 child-years. The adjusted incidence rate ratio was 0.60 (95% confidence interval [CI] 0.40, 0.91) during the vaccine period versus the pre-vaccine period, indicating a lower incidence of watery diarrhea in the community during the vaccine period.

MeSH Terms (11)

Child, Preschool Cohort Studies Diarrhea Female Humans Incidence Infant Male Nicaragua Rotavirus Infections Rotavirus Vaccines

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