Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P
Dev Cell. 2013 26 (1): 86-100

PMID: 23810513 · DOI:10.1016/j.devcel.2013.05.018

MeSH Terms (19)

Animals Basic Helix-Loop-Helix Transcription Factors Blood Glucose Cell Differentiation Cell Lineage Cell Movement Cellular Reprogramming Diabetes Mellitus, Experimental Epithelial-Mesenchymal Transition Gene Expression Regulation Glucagon-Secreting Cells Homeodomain Proteins Hypertrophy Insulin-Secreting Cells Mice Nerve Tissue Proteins Paired Box Transcription Factors Pancreatic Ducts Streptozocin

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