Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor.

Ito K, Van Kaer L, Bonneville M, Hsu S, Murphy DB, Tonegawa S
Cell. 1990 62 (3): 549-61

PMID: 2379238 · DOI:10.1016/0092-8674(90)90019-b

The gamma delta T cell receptor (TCR) derived from the mouse KN6 T cell hybridoma recognizes an autologous determinant encoded by a broadly expressed gene mapping in the TL region of the major histocompatibility complex (MHC). We have cloned the gene and demonstrated that it is a novel class I gene (designated 27b) belonging to a hitherto undescribed TL region gene cluster in strain C57BL/6. The BALB/c allele of 27b, gene T17c, is defective because it lacks an appropriate splice acceptor site, which explains the lack of recognition of BALB/c stimulator cells by the KN6 cells. We propose that gamma delta TCR and nonclassical MHC and MHC-related class I molecules have coevolved to recognize a conserved set of endogenous and foreign determinants.

MeSH Terms (18)

Amino Acid Sequence Animals Base Sequence DNA Probes Exons Genes, MHC Class I Histocompatibility Antigens Class I Introns Lymphocyte Activation Lymphocytes Mice Mice, Inbred BALB C Mice, Inbred Strains Molecular Sequence Data Receptors, Antigen, T-Cell RNA Splicing T-Lymphocytes Transfection

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