In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.

Soeiro Mde N, de Souza EM, da Silva CF, Batista Dda G, Batista MM, Pavão BP, Araújo JS, Aiub CA, da Silva PB, Lionel J, Britto C, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GI
Antimicrob Agents Chemother. 2013 57 (9): 4151-63

PMID: 23774435 · PMCID: PMC3754355 · DOI:10.1128/AAC.00070-13

MeSH Terms (18)

14-alpha Demethylase Inhibitors Animals Chagas Disease Drug Resistance Endoplasmic Reticulum Golgi Apparatus Imidazoles Male Mice Microscopy, Electron, Transmission Nitroimidazoles Oxadiazoles Protozoan Proteins Sterol 14-Demethylase Thiazoles Triazoles Trypanocidal Agents Trypanosoma cruzi

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