Cohort profile: The study of respiratory pathogens in Andean children.

Grijalva CG, Griffin MR, Edwards KM, Williams JV, Gil AI, Verastegui H, Hartinger SM, Vidal JE, Klugman KP, Lanata CF
Int J Epidemiol. 2014 43 (4): 1021-30

PMID: 23771719 · PMCID: PMC4121548 · DOI:10.1093/ije/dyt065

We investigated respiratory pathogens in a prospective cohort study of young children living in the Peruvian Andes. In the study we assessed viral respiratory infections among young children, and explored interactions of viruses with common respiratory bacteria, especially Streptococcus pneumoniae. Through weekly household visits, data were collected on the signs and symptoms of acute respiratory illness (ARI), nasal samples were collected to test for viruses during episodes of ARI, and nasopharyngeal samples were collected on a monthly basis to monitor bacterial colonisation. We also collected data on vaccination coverage, patterns of social mixing, geographic information, and environmental and socio-demographic variables. Understanding the interaction of respiratory viruses with bacteria and its impact on the burden and severity of ARIs in rural areas of developing countries is critical to designing strategies for preventing such infections.

Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2013; all rights reserved.

MeSH Terms (20)

Acute Disease Child, Preschool Cohort Studies Female Haemophilus Infections Haemophilus influenzae Humans Infant Infant, Newborn Influenza, Human Influenza Vaccines Male Peru Pneumococcal Infections Pneumococcal Vaccines Prospective Studies Respiratory Tract Infections Staphylococcal Infections Staphylococcus aureus Streptococcus pneumoniae

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