Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients.

Ascierto ML, Idowu MO, Zhao Y, Khalak H, Payne KK, Wang XY, Dumur CI, Bedognetti D, Tomei S, Ascierto PA, Shanker A, Bear HD, Wang E, Marincola FM, De Maria A, Manjili MH
J Transl Med. 2013 11: 145

PMID: 23758773 · PMCID: PMC3694475 · DOI:10.1186/1479-5876-11-145

BACKGROUND - Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.

METHODS - Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes.

RESULTS - By analyzing primary breast cancer specimens derived from patients who experienced either 58-116 months (~5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (~1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis.

CONCLUSIONS - The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment.

MeSH Terms (17)

Antigens, CD1d Breast Neoplasms Cell Adhesion Molecules Cell Count Disease-Free Survival Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Killer Cells, Natural Lymphocyte Activation Lymphocyte Function-Associated Antigen-1 Neoplasm Recurrence, Local Recurrence Signal Transduction Support Vector Machine Treatment Outcome

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