Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.

Jia P, Jin H, Meador CB, Xia J, Ohashi K, Liu L, Pirazzoli V, Dahlman KB, Politi K, Michor F, Zhao Z, Pao W
Genome Res. 2013 23 (9): 1434-45

PMID: 23733853 · PMCID: PMC3759720 · DOI:10.1101/gr.152322.112

MeSH Terms (13)

Antineoplastic Agents Cell Line, Tumor DNA Copy Number Variations Drug Resistance, Neoplasm ErbB Receptors Genome, Human High-Throughput Nucleotide Sequencing Humans INDEL Mutation Lung Neoplasms Polymorphism, Single Nucleotide Protein Kinase Inhibitors Sequence Analysis, DNA

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