ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.

Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD
ACS Chem Neurosci. 2013 4 (9): 1278-86

PMID: 23730969 · PMCID: PMC3778424 · DOI:10.1021/cn400062a

MeSH Terms (23)

Animals Anticonvulsants Calcium Signaling Dose-Response Relationship, Drug Drug Evaluation, Preclinical Electroshock G Protein-Coupled Inwardly-Rectifying Potassium Channels HEK293 Cells High-Throughput Screening Assays Humans Injections, Intraperitoneal Mice Microsomes, Liver Molecular Structure Patch-Clamp Techniques Pentylenetetrazole Phenylurea Compounds Pyrazoles Rats Receptors, Metabotropic Glutamate Recombinant Proteins Seizures Valproic Acid

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