Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM).

Wenthur CJ, Morrison R, Felts AS, Smith KA, Engers JL, Byers FW, Daniels JS, Emmitte KA, Conn PJ, Lindsley CW
J Med Chem. 2013 56 (12): 5208-12

PMID: 23718281 · PMCID: PMC3769689 · DOI:10.1021/jm400439t

MeSH Terms (11)

Allosteric Regulation Animals Brain Drug Discovery Humans Inhibitory Concentration 50 Mice Piperidines Rats Receptors, Metabotropic Glutamate Substrate Specificity

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