The Genotype-Tissue Expression (GTEx) project.

GTEx Consortium
Nat Genet. 2013 45 (6): 580-5

PMID: 23715323 · PMCID: PMC4010069 · DOI:10.1038/ng.2653

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.

MeSH Terms (11)

Consensus Development Conferences, NIH as Topic Gene Expression Gene Expression Profiling Genome-Wide Association Study Government Programs Humans Molecular Sequence Annotation Organ Specificity Quantitative Trait Loci Tissue Banks United States

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