Warfarin pharmacogenomics in children.

Vear SI, Stein CM, Ho RH
Pediatr Blood Cancer. 2013 60 (9): 1402-7

PMID: 23682017 · PMCID: PMC3786327 · DOI:10.1002/pbc.24592

Warfarin is the most commonly used oral anticoagulant worldwide. Warfarin has a narrow therapeutic index, requiring frequent monitoring of the INR to achieve therapeutic anticoagulation. The role of pharmacogenomics in warfarin disposition and response has been well established in adults, but remains unclear for pediatric patients. In this review, we focus on the important CYP2C9 and VKORC1 variants involved in warfarin response, our current understanding of warfarin disposition and pharmacogenomics, and recent warfarin pharmacogenetic studies in pediatric patients. Finally, we discuss the need for future pediatric studies and the clinical implications of developing pharmacogenetic-based dosing algorithms in children.

Copyright © 2013 Wiley Periodicals, Inc.

MeSH Terms (16)

Adolescent Adult Algorithms Anticoagulants Aryl Hydrocarbon Hydroxylases Child Child, Preschool Cytochrome P-450 CYP2C9 Female Humans International Normalized Ratio Male Mixed Function Oxygenases Pharmacogenetics Vitamin K Epoxide Reductases Warfarin

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