Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia.

Bhatnagar P, Keefer JR, Casella JF, Barron-Casella EA, Bean CJ, Hooper CW, Payne AB, Arking DE, Debaun MR
Pediatr Blood Cancer. 2013 60 (10): E125-7

PMID: 23677903 · PMCID: PMC4387562 · DOI:10.1002/pbc.24588

The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value = 0.02).

Copyright © 2013 Wiley Periodicals, Inc.

MeSH Terms (11)

Adolescent Anemia, Sickle Cell Child Child, Preschool Constriction, Pathologic Female Fetal Hemoglobin Follow-Up Studies Humans Male Pain

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