T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.

Sandy AR, Chung J, Toubai T, Shan GT, Tran IT, Friedman A, Blackwell TS, Reddy P, King PD, Maillard I
J Immunol. 2013 190 (11): 5818-28

PMID: 23636056 · PMCID: PMC3660433 · DOI:10.4049/jimmunol.1203452

MeSH Terms (16)

Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cytotoxicity, Immunologic Enzyme Activation Gene Expression Regulation Graft vs Host Disease Interferon-gamma Lymphocyte Activation Mice Mitogen-Activated Protein Kinases NF-kappa B Proto-Oncogene Proteins p21(ras) Receptors, Notch T-Box Domain Proteins T-Lymphocytes, Regulatory

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