Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.

Young CD, Pfefferle AD, Owens P, Kuba MG, Rexer BN, Balko JM, Sánchez V, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL
Cancer Res. 2013 73 (13): 4075-85

PMID: 23633485 · PMCID: PMC3702683 · DOI:10.1158/0008-5472.CAN-12-4579

MeSH Terms (25)

Animals Antineoplastic Agents Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases Female Gene Expression Humans Hyperplasia Lapatinib Mammary Glands, Animal Mammary Neoplasms, Experimental Mice Mice, Nude Mice, Transgenic Mutation, Missense Neoplasm Transplantation Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Protein Binding Quinazolines Receptor, ErbB-2 Receptor, ErbB-3 Signal Transduction Transcriptome Tumor Burden

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