Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance.

Donahue MJ, Hussey E, Rane S, Wilson T, van Osch M, Hartkamp N, Hendrikse J, Ally BA
J Magn Reson Imaging. 2014 39 (2): 377-86

PMID: 23633160 · PMCID: PMC3735670 · DOI:10.1002/jmri.24150

PURPOSE - To evaluate how flow territory asymmetry and/or the distribution of blood through collateral pathways may adversely affect the brain's ability to respond to age-related changes in brain function. These patterns have been investigated in cerebrovascular disease; however, here we evaluated how flow-territory asymmetry related to memory generally in older adults.

MATERIALS AND METHODS - A multi-faceted MRI protocol, including vessel-encoded arterial spin labeling capable of flow territory mapping, was applied to assess how flow territory asymmetry; memory performance (CERAD-Immediate Recall); cortical cerebral blood flow (CBF), white matter lesion (WML) count, and cortical gray matter volume were related in older healthy control volunteers (HC; n = 15; age = 64.5 ± 7 years) and age-matched mild cognitive impairment volunteers (MCI; n = 7; age = 62.7 ± 3.7 years).

RESULTS - An inverse relationship was found between memory performance and flow territory asymmetry in HC volunteers (P = 0.04), which reversed in MCI volunteers (P = 0.04). No relationship was found between memory performance and cortical tissue volume in either group (P > 0.05). Group-level differences for HC volunteers performing above versus below average on CERAD-I were observed for flow territory asymmetry (P < 0.02) and cortical volume (P < 0.05) only.

CONCLUSION - Findings suggest that flow territory asymmetry may correlate more sensitively with memory performance than CBF, atrophy and WML count in older adults.

Copyright © 2013 Wiley Periodicals, Inc.

MeSH Terms (18)

Adult Aging Blood Flow Velocity Brain Cerebral Angiography Cerebrovascular Circulation Female Humans Magnetic Resonance Angiography Male Memory Memory Disorders Middle Aged Nerve Fibers, Myelinated Reproducibility of Results Sensitivity and Specificity Spin Labels Verbal Behavior

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