Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus.

Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP
Proc Natl Acad Sci U S A. 2013 110 (20): 8206-11

PMID: 23630262 · PMCID: PMC3657828 · DOI:10.1073/pnas.1303674110

MeSH Terms (21)

Animals Anti-Bacterial Agents Bacterial Proteins Chromatography, High Pressure Liquid Combinatorial Chemistry Techniques Drug Design Fermentation Gene Expression Regulation, Bacterial Glycolysis Heme Heme Oxygenase (Decyclizing) Inhibitory Concentration 50 Leukocytes Mass Spectrometry Mice Microscopy, Electron, Scanning Naphthols Phagocytes Pyrazoles Staphylococcal Infections Staphylococcus aureus

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