Determining the effectiveness of the pentavalent rotavirus vaccine against rotavirus hospitalizations and emergency department visits using two study designs.

Donauer S, Payne DC, Edwards KM, Szilagyi PG, Hornung RW, Weinberg GA, Chappell J, Hall CB, Parashar UD, Staat MA
Vaccine. 2013 31 (24): 2692-7

PMID: 23583814 · PMCID: PMC4618546 · DOI:10.1016/j.vaccine.2013.03.072

The objective of this study is to determine the vaccine effectiveness (VE) of the pentavalent rotavirus vaccine (RV5) for preventing rotavirus-related hospitalizations and emergency department (ED) visits during the 2006-07 and 2007-08 rotavirus seasons using two study designs. Active, prospective population-based surveillance was conducted to identify cases of laboratory-confirmed rotavirus-related hospitalizations and ED visits to be used in case-cohort and case-control designs. VE was calculated using one comparison group for the case-cohort method and two comparison groups for the case-control method. The VE estimates produced by the three analyses were similar. Three doses of RV5 were effective for preventing rotavirus-related hospitalizations and ED visits in each analysis, with VE estimated as 92% in all three analyses. Two doses of RV5 were also effective, with VE ranging from 79% to 83%. A single dose was effective in the case-cohort analysis, but was not significant in either of the case-control analyses. The case-cohort and the case-control study designs produced the same VE point estimates for completion of the three dose series. Two and three doses of RV5 were effective in preventing rotavirus-related hospitalizations and ED visits.

Copyright © 2013 Elsevier Ltd. All rights reserved.

MeSH Terms (20)

Case-Control Studies Child Child, Preschool Cohort Studies Emergency Service, Hospital Female Gastroenteritis Hospitalization Humans Infant Male New York Ohio Proportional Hazards Models Prospective Studies Rotavirus Rotavirus Infections Rotavirus Vaccines Tennessee Vaccines, Attenuated

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