Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo.

Escalante AM, McGrath RT, Karolak MR, Dorr RT, Lynch RM, Landowski TH
Cancer Chemother Pharmacol. 2013 71 (6): 1567-76

PMID: 23572175 · PMCID: PMC3669633 · DOI:10.1007/s00280-013-2156-3

MeSH Terms (19)

Animals Antineoplastic Agents Apoptosis Autophagy Boronic Acids Bortezomib Calpain Cell Line, Tumor Cell Survival Drug Synergism HIV Protease Inhibitors Humans Mice Mice, SCID Multiple Myeloma Nelfinavir Pyrazines RNA, Small Interfering Xenograft Model Antitumor Assays

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