Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?

Knollmann BC
Circ Res. 2013 112 (6): 969-76; discussion 976

PMID: 23569106 · PMCID: PMC3667201 · DOI:10.1161/CIRCRESAHA.112.300567

This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questions: Which clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using iPSC-CM to personalize antiarrhythmic drug therapy? The review also discusses the pros and cons of using the iPSC-CM technology for modeling specific genetic arrhythmia disorders, such as long QT syndrome, Brugada Syndrome, or Catecholaminergic Polymorphic Ventricular Tachycardia.

MeSH Terms (4)

Arrhythmias, Cardiac Humans Induced Pluripotent Stem Cells Myocytes, Cardiac

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