Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.

Sang J, Acquaviva J, Friedland JC, Smith DL, Sequeira M, Zhang C, Jiang Q, Xue L, Lovly CM, Jimenez JP, Shaw AT, Doebele RC, He S, Bates RC, Camidge DR, Morris SW, El-Hariry I, Proia DA
Cancer Discov. 2013 3 (4): 430-43

PMID: 23533265 · PMCID: PMC4086149 · DOI:10.1158/2159-8290.CD-12-0440

MeSH Terms (23)

Adult Anaplastic Lymphoma Kinase Animals Antineoplastic Agents Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Crizotinib Drug Resistance, Neoplasm Female HSP90 Heat-Shock Proteins Humans Lung Neoplasms Male Mice Mice, Nude Mice, SCID Pyrazoles Pyridines Receptor Protein-Tyrosine Kinases Triazoles Tumor Burden Xenograft Model Antitumor Assays Young Adult

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