In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.

Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O
Cell Metab. 2013 17 (3): 372-85

PMID: 23473032 · PMCID: PMC4003458 · DOI:10.1016/j.cmet.2013.02.002

MeSH Terms (16)

Animals Basic Helix-Loop-Helix Transcription Factors Carbon Isotopes Carboxylic Acids Carcinoma, Renal Cell Cell Line, Tumor Citrates Extracellular Fluid Gas Chromatography-Mass Spectrometry Glutamine Humans Magnetic Resonance Spectroscopy Mice Models, Biological Oxidation-Reduction Von Hippel-Lindau Tumor Suppressor Protein

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