Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.

Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG
J Biol Chem. 2013 288 (18): 12627-44

PMID: 23471973 · PMCID: PMC3642310 · DOI:10.1074/jbc.M113.452367

MeSH Terms (16)

Amino Acid Substitution Animals Central Nervous System Depressants Chlorocebus aethiops COS Cells Cytochrome P-450 CYP2E1 Ethanol Hep G2 Cells Humans Liver Mitochondria Mitochondrial Proteins Models, Biological Mutation, Missense Oxygen Consumption Protein Transport

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