Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.

Aldred KJ, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
Nucleic Acids Res. 2013 41 (8): 4628-39

PMID: 23460203 · PMCID: PMC3632122 · DOI:10.1093/nar/gkt124

MeSH Terms (14)

Anti-Bacterial Agents Bacillus anthracis Cations, Divalent Ciprofloxacin DNA DNA Cleavage DNA Topoisomerase IV Drug Resistance Magnesium Metals Mutation Quinazolinones Quinolones Water

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