Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.

Karuturi R, Al-Horani RA, Mehta SC, Gailani D, Desai UR
J Med Chem. 2013 56 (6): 2415-28

PMID: 23451707 · PMCID: PMC3625964 · DOI:10.1021/jm301757v

MeSH Terms (12)

Allosteric Regulation Biomimetic Materials Catalytic Domain Drug Discovery Factor XIa Glycosaminoglycans Heparin Humans Hydrophobic and Hydrophilic Interactions Protease Inhibitors Quinazolinones Sulfates

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