Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth.

Andriani G, Amata E, Beatty J, Clements Z, Coffey BJ, Courtemanche G, Devine W, Erath J, Juda CE, Wawrzak Z, Wood JT, Lepesheva GI, Rodriguez A, Pollastri MP
J Med Chem. 2013 56 (6): 2556-67

PMID: 23448316 · PMCID: PMC3612894 · DOI:10.1021/jm400012e

MeSH Terms (11)

14-alpha Demethylase Inhibitors Absorption Biological Availability Drug Discovery Ligands Models, Molecular Protein Conformation Sterol 14-Demethylase Structure-Activity Relationship Trypanocidal Agents Trypanosoma cruzi

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