Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.

Gregory KJ, Nguyen ED, Reiff SD, Squire EF, Stauffer SR, Lindsley CW, Meiler J, Conn PJ
Mol Pharmacol. 2013 83 (5): 991-1006

PMID: 23444015 · PMCID: PMC3629835 · DOI:10.1124/mol.112.083949

MeSH Terms (16)

Alkynes Allosteric Regulation Allosteric Site Amino Acids Animals Cell Line Glutamic Acid HEK293 Cells Humans Ligands Point Mutation Pyridines Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Transfection

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