Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.

Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM
J Med Chem. 2013 56 (6): 2429-46

PMID: 23432095 · PMCID: PMC3638264 · DOI:10.1021/jm3017656

MeSH Terms (16)

3-Hydroxysteroid Dehydrogenases Aldo-Keto Reductase Family 1 Member C3 Catalytic Domain Enzyme Inhibitors Genes, Reporter HeLa Cells Humans Hydroxyprostaglandin Dehydrogenases Indomethacin Male Models, Molecular Neoplasm Metastasis Orchiectomy Prostatic Neoplasms Receptors, Androgen Substrate Specificity

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