Associations of leukocyte telomere length with body anthropometric indices and weight change in Chinese women.

Cui Y, Gao YT, Cai Q, Qu S, Cai H, Li HL, Wu J, Ji BT, Yang G, Chow WH, Shu XO, Zheng W
Obesity (Silver Spring). 2013 21 (12): 2582-8

PMID: 23408544 · PMCID: PMC3676725 · DOI:10.1002/oby.20321

OBJECTIVE - This study evaluated associations of telomere length with various anthropometric indices of general and abdominal obesity, as well as weight change.

DESIGN AND METHODS - The study included 2,912 Chinese women aged 40-70 years. Monochrome multiplex quantitative polymerase chain reaction was applied to measure relative telomere length.

RESULTS - Telomere length was inversely associated with body mass index (BMI), waist circumference, waist-to-height ratio, weight, and hip circumference (Ptrend = 0.005, 0.004, 0.004, 0.010, and 0.026, respectively), but not waist-to-hip ratio (Ptrend = 0.116) or height (Ptrend = 0.675). Weight change since age 50 was further evaluated among women over age 55. Women who maintained their weight within ±5% since age 50, particularly within a normal range (BMI = 18.5-24.9 kg/m(2) ), or reduced their weight from overweight (BMI = 25-29.9 kg/m(2) ) or obesity (BMI ≥30 kg/m(2) ) to normal range, had a longer mean of current telomere length than women who gained weight since age 50 (Ptrend = 0.025), particularly those who stayed in obesity or gained weight from normal range or overweight to obesity (P = 0.023).

CONCLUSION - Our findings show that telomere shortening is associated with obesity and that maintaining body weight within a normal range helps maintain telomere length.

Copyright © 2013 The Obesity Society.

MeSH Terms (19)

Adult Aged Anthropometry Asian Continental Ancestry Group China Female Humans Leukocytes Middle Aged Neoplasms Obesity Obesity, Abdominal Overweight Prospective Studies Risk Factors Socioeconomic Factors Telomere Waist-Hip Ratio Weight Gain

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