Controlled branching of polyglycidol and formation of protein-glycidol bioconjugates via a graft-from approach with "PEG-like" arms.

Spears BR, Waksal J, McQuade C, Lanier L, Harth E
Chem Commun (Camb). 2013 49 (24): 2394-6

PMID: 23370543 · DOI:10.1039/c3cc38369e

The control of the branching in polyglycidols as semibranched alternatives to traditional polyglycidols is presented. The relative abundance of dendritic carbons is lowered by five-fold compared to hyperbranched polyglycidols. It is the first example of tailoring the branching in polyglycidol and creating protein-glycidol bioconjugates as alternatives to pegylated biostructures.

MeSH Terms (9)

Animals Cattle Epoxy Compounds Polyethylene Glycols Polymers Propanols Propylene Glycols Proteins Serum Albumin, Bovine

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