The quiet renaissance of protein nuclear magnetic resonance.

Barrett PJ, Chen J, Cho MK, Kim JH, Lu Z, Mathew S, Peng D, Song Y, Van Horn WD, Zhuang T, Sönnichsen FD, Sanders CR
Biochemistry. 2013 52 (8): 1303-20

PMID: 23368985 · PMCID: PMC3592982 · DOI:10.1021/bi4000436

From roughly 1985 through the start of the new millennium, the cutting edge of solution protein nuclear magnetic resonance (NMR) spectroscopy was to a significant extent driven by the aspiration to determine structures. Here we survey recent advances in protein NMR that herald a renaissance in which a number of its most important applications reflect the broad problem-solving capability displayed by this method during its classical era during the 1970s and early 1980s.

MeSH Terms (10)

Animals Drug Discovery History, 20th Century History, 21st Century Humans Models, Molecular Nuclear Magnetic Resonance, Biomolecular Protein Conformation Protein Interaction Mapping Proteins

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