A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.

Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW, Niswender CM, Xiang Z, Conn PJ
Mol Pharmacol. 2013 83 (4): 835-47

PMID: 23348500 · PMCID: PMC3608436 · DOI:10.1124/mol.112.082891

MeSH Terms (15)

Allosteric Regulation Animals Benzamides Binding Sites Cells, Cultured Female HEK293 Cells Humans Male Phthalimides Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Signal Transduction

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