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High-fat diet acutely affects circadian organisation and eating behavior.

Pendergast JS, Branecky KL, Yang W, Ellacott KL, Niswender KD, Yamazaki S
Eur J Neurosci. 2013 37 (8): 1350-6

PMID: 23331763 · PMCID: PMC3645495 · DOI:10.1111/ejn.12133

The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.

© 2013 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

MeSH Terms (9)

Animals Circadian Rhythm Diet, High-Fat Feeding Behavior Luminescent Measurements Male Mice Mice, Inbred C57BL Motor Activity

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