Intraorbital metastasis from solitary fibrous tumor.

Patel MM, Jakobiec FA, Zakka FR, Du R, Annino DJ, Borboli-Gerogiannis S, Daniels AB
Ophthalmic Plast Reconstr Surg. 2013 29 (3): e76-9

PMID: 23328780 · DOI:10.1097/IOP.0b013e318272f311

Solitary fibrous tumor (SFT) is a rare spindle cell tumor of mesenchymal origin that usually arises from pleura or pericardium but can also arise from many extraserosal sites. Although more than 50 cases of primary SFT of the orbit have been reported, there are no reports to date of a malignant nonophthalmic SFT metastasizing in the orbital soft tissues (although sphenoid wing bony involvement has been reported). The authors report here the first case of a patient with intraorbital metastasis of a CD34-positive malignant SFT. The patient was a 57-year-old man with a history of malignant pleural SFT and a prior kidney metastasis. He presented with the rapid appearance of proptosis and massive conjunctival chemosis preventing eyelid closure, and he was found to have a well-circumscribed metastasis to his lateral rectus muscle. Surgical excision cured his ocular symptoms, although he died 3 months later from brain and widespread metastases.

MeSH Terms (15)

Antigens, CD34 Antineoplastic Agents Biomarkers, Tumor Combined Modality Therapy Fatal Outcome Humans Kidney Neoplasms Magnetic Resonance Imaging Male Middle Aged Ophthalmologic Surgical Procedures Orbital Neoplasms Pleural Neoplasms Proto-Oncogene Proteins c-bcl-2 Solitary Fibrous Tumor, Pleural

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