No association between ovarian cancer susceptibility variants and breast cancer risk among Chinese women.

Ma X, Cai Q, Delahanty RJ, Shu XO, Zhang B, Lu W, Gao YT, Zheng W, Long J, Beeghly-Fadiel A
Cancer Epidemiol Biomarkers Prev. 2013 22 (3): 467-9

PMID: 23292081 · PMCID: PMC3596432 · DOI:10.1158/1055-9965.EPI-12-1365

BACKGROUND - As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer.

METHODS - Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r(2) ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls.

RESULTS - No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05).

CONCLUSIONS - Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women.

IMPACT - These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women.

MeSH Terms (12)

Biomarkers, Tumor Breast Neoplasms Case-Control Studies China Disease Susceptibility Female Humans Meta-Analysis as Topic Ovarian Neoplasms Polymorphism, Single Nucleotide Prognosis Risk Factors

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